Independent Evidence – Updated Autumn 2015

The Magic lamp is based on the original NASA research and specific wavelengths of light plus past and ongoing Independent Research. We use a combination of particular wavelengths that are designed from this evidence to help the Magic Lamp in its aim to be effective and efficient. These are just some of the papers and independent research and conclusions that we relied on in our extensive programme. They and many more (67 pages written and supplied for CE approval) are the basis of any help and benefits that that the Magic Lamp might provide please also read our disclaimer.

This evidence Includes: - NASA, Energy, Pain relief, Arthritis, MS, Wound Healing, inflammation, protection, Skin texture and Fine lines

Short summary A NASA discovery has current applications in orthapadaedics

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272231/


Light therapy to treat autoimmune disease

http://spie.org/newsroom/technical-articles/5900-light-therapy-to-treat-autoimmune-disease

Jeri-Anne Lyons

Experiments in an animal model of multiple sclerosis demonstrate the therapeutic potential of 670nm light treatment.

24 April 2015, SPIE Newsroom. DOI: 10.1117/2.1201504.005900



 1. SPEED – Might be immediate (chronic neck pain)

  1. Scientists discover near-infrared light turbocharges chemical reactions providing cellular energy

Shining red light on skin or cells in a dish gives an instant energy boost that could help heal wounds, relieve pain

The red light seems to alter the physical properties of water, which turbocharges the chemical reactions that provide a cell's energy. 

http://www.sott.net/article/298907-Scientists-discover-near-infrared-light-turbocharges-chemical-reactions-providing-cellular-energy

Journal reference: Scientific Reports, DOI: 10.1038/srep12029


2 *Immediate pain relief – immediate and for 22 weeks* Independent Evidence

There appears to be more firm evidence to support the success of LLLT in alleviating pain and treating chronic joint disorders, than in healing wounds. A review of 16 randomized clinical trials including a total of 820 patients found that LLLT reduces acute neck pain immediately after treatment, and up to 22 weeks after completion of treatment in patients with chronic neck pain.1 LLLT has also been shown to relieve pain because of cervical dentinal hypersensitivity,2 or from periodontal pain during orthodontic tooth movement.3 A study of 88 randomized controlled trials indicated that LLLT can significantly reduce pain and improve health in chronic joint disorders such as osteoarthritis, patellofemoral pain syndrome, and mechanical spine disorder Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active

Treatment controlled trials Dr Roberta T Chow, MBBS  Prof Mark I Johnson, PhD Prof Rodrigo AB Lopes-Martins, PhD, Prof Jan M Bjordal, PTPuished Online: 13 November 2009

Background

Neck pain is a common and costly condition for which pharmacological management has limited evidence of efficacy and side-effects. Low-level laser therapy (LLLT) is a relatively uncommon, non-invasive treatment for neck pain, in which non-thermal laser irradiation is applied to sites of pain. We did a systematic review and meta-analysis of randomised controlled trials to assess the efficacy of LLLT in neck pain.

Methods

We searched computerised databases comparing efficacy of LLLT using any wavelength with placebo or with active control in acute or chronic neck pain. Effect size for the primary outcome, pain intensity, was defined as a pooled estimate of mean difference in change in mm on 100 mm visual analogue scale.

Findings

We identified 16 randomised controlled trials including a total of 820 patients. In acute neck pain, results of two trials showed a relative risk (RR) of 1·69 (95% CI 1·22–2·33) for pain improvement of LLLT versus placebo. Five trials of chronic neck pain reporting categorical data showed an RR for pain improvement of 4·05 (2·74–5·98) of LLLT. Patients in 11 trials reporting changes in visual analogue scale had pain intensity reduced by 19·86 mm (10·04–29·68). Seven trials provided follow-up data for 1–22 weeks after completion of treatment, with short-term pain relief persisting in the medium term with a reduction of 22·07 mm (17·42–26·72). Side-effects from LLLT were mild and not different from those of placebo.

Interpretation

We show that LLLT reduces pain immediately after treatment in acute neck pain and up to 22 weeks after completion of treatment in patients with chronic neck pain.

Funding

None.

Some other references

3.

  1. Chow RT, Johnson MI, Lopes-Martins RA, Bjordal JM. Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled (trials. 2009;374:1897–1908. [PubMed] as above
  2. Sandford MA, Walsh LJ. Thermal effects during desensitisation of teeth with gallium-aluminium-arsenide lasers. Periodontology. 1994;15:25–30.
  3. .Wahl G, Bastanier S. Soft laser in postoperative care in dentoalveolar treatment.  1991;100:512–515. [PubMed]
  4. .Bjordal JM, Couppe C, Chow RT, Tuner J, Ljunggren EA. A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother. 2003;49:107–116. [PubMed]
  5. .Chow RT, Johnson MI, Lopes-Martins RA, Bjordal JM. Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials.  2009;374:1897–1908. [PubMed]

Lasers Med Sci. 2014 Nov;29(6):1839-47. doi: 10.1007/s10103-014-1592-6. Epub 2014 May 21.

Adjunctive use of combination of super-pulsed laser and light-emitting diodes phototherapy on nonspecific knee pain: double-blinded randomized placebo-controlled trial.

Leal-Junior EC1Johnson DSSaltmarche ADemchak T.

Author information

Abstract

Phototherapy with low-level laser therapy (LLLT) and light-emitting diode therapy (LEDT) has arisen as an interesting alternative to drugs in treatments of musculoskeletal disorders. However, there is a lack of studies investigating the effects of combined use of different wavelengths from different light sources like lasers and light-emitting diodes (LEDs) in skeletal muscle disorders. With this perspective in mind, this study aimed to investigate the effects of phototherapy with combination of different light sources on nonspecific knee pain. It was performed a randomized, placebo-controlled, double-blinded clinical trial. Eighty-six patients rated 30 or greater on the pain visual analogue scale (VAS) were recruited and included in study. Patients of LLLT group received 12 treatments with active phototherapy (with 905 nm super-pulsed laser and 875 and 640 nm LEDs, Manufactured by Multi Radiance Medical, Solon, OH, USA) and conventional treatment (physical therapy or chiropractic care), and patients of placebo group were treated at same way but with placebo phototherapy device. Pain assessments (VAS) were performed at baseline, 4th, 7th, and 10th treatments, after the completion of treatments and at 1-month follow-up visit. Quality of life assessments (SF-36®) were performed at baseline, after the completion of treatments and at 1-month follow-up visit. Our results demonstrate that phototherapy significantly decreased pain (p < 0.05) from 10th treatment to follow-up assessments and significantly improved (p < 0.05) SF-36® physical component summary at posttreatments and follow-up assessments compared to placebo.


4.

We conclude that combination of super-pulsed laser, red and infrared LEDs is effective to decrease pain and improve quality of life in patients with knee pain.

PMID:24844921 Br J Sports Med 2011;45:e1 doi:10.1136/bjsm.2010.081554.56

Low-level laser therapy (LLLT) for discogenic back pain

  1. N Malliaropoulos1,2,
  2. A Akritidou2,
  3. I Tsifountoudis3,
  4. K Tsitas1

+Author Affiliations

1.      1National Track & Field Centre, Sports Injury Clinic, Sports Medicine Clinic of S.E.G.A.S., Thessaloniki, Greece 2.      2Thessaloniki SPORTS Medicine Clinic, Aristotle University of Thessaloniki, Thessaloniki, Greece 3.      3Department of Radiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece


Abstract

The aim of this study was to investigate the effect of low-level laser therapy (LLLT) on low back pain documented by history, clinical examination, MRI findings of the Lumbar Spine and patients' pain scores. 39 individuals with diagnosis of low back pain were enrolled in randomised, double-blind, placebo-controlled trial, but 32 participants completed the therapeutic protocol. After enrolment, symptomatic individuals were randomly assigned to receive LLLT, or identical placebo, for 6 weeks. MRI was performed at baseline of therapy. The subjective low back pain was recorded at baseline and after treatment on a visual analogue scale. After LLLT, low back pain in both groups showed significant change over the experimental period and there was a significant difference (before treatment and after treatment) in discogenic back pain between the two groups. Pain estimation on the visual analogue scale had improved significantly in all test situations (after night rest, daily activities) after LLLT when compared with that of the placebo group. Additionally when the difference in pain scores was compared between the two groups the change was statistically significant.

 

5.

In summary, while MRI findings are able to depict the morphologic changes related to discogenic back pain, 905 nm gallium-arsenide infrared laser may contribute to healing and pain reduction in discogenic low back pain.

Latest exciting research April 2015

Blue light to help Pain relief – 465nm opens gateways to natural relief (including dopamaine)

Light-- not pain- Light killing drugs -- used to activate brain's opioid receptors

Date:

April 30, 2015

Source:

Washington University in St. Louis

Summary:

Neuroscientists have attached the light-sensing protein rhodopsin to opioid receptor parts to activate the receptor pathways using light from a laser fiber-optic device. They also influenced the behaviour of mice using light, rather than drugs, to activate the reward response. When an opioid receptor is exposed to a pain-killing drug, it initiates activity in specific chemical pathways in the brain and spinal cord. And when the researchers shone light on the receptors that contained rhodopsin, the same cellular pathways were activated. Neurons in that part of the brain release chemicals such as dopamine that create feelings of euphoria.

Reference

http://www.sciencedaily.com/releases/2015/04/150430124005.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28Health+%26+Medicine+News+--+ScienceDaily%29

http://www.cell.com/neuron/fulltext/S0896-6273(15)00290-1

Additionally, we show that opto-MOR is maximally activated with 465 nm light and shows less efficacy at other wavelengths in cAMP inhibition (525, 630, and 660 nm) (Figure 1G). 


6.

For help with reduction of inflammation and help with protection from damage

Helps better blood flow, oxygen supply, muscle relaxation, supply of nutrients

Blue LED light activates natural biochemical processes in the body without the side effects medication can have.  Blue LED light at a wavelength of 453 nm has no damaging effect on various skin cell types up to a daily exposure of 250 J/cm², which means that it is not toxic. [Kolb-Bachofen V, Final report of the BMBF joint research project. 2010, University of Düsseldorf]. The suitability of LEDs for each medical treatment in terms of treatment efficacy and safety is tested in-depth in clinical studies with patients.

The release of NO is also part of a natural process. The skin contains a relatively high concentration of nitrite and S-nitrosated proteins, which can be photolytically cleaved by blue light to release NO. This reaction was already observed with UV light [Liebmann J et al. JID. 2010; 130: 259 – 269]. The fact that similar results can be achieved with blue LED light makes it possible to use the positive effects of NO without the potentially damaging side effects of UV radiation (cell death and cancer).

Blue light also has a positive effect on regulation of inflammatory processes in the body. Studies confirmed that irradiation with blue light suppresses the activation of certain immune cells, the dendritic cells. As a result, the proliferation of inflammation enhancing T-cells and the release of inflammatory mediators (cytokines) is reduced [Fischer M et al. Experimental Dermatology. 2013; 22:554-563].

http://www.nature.com/jid/journal/v130/n1/pdf/jid2009194a.pdf

Arthritis

Arthritic Pain Relief, the Lancet Review for (LLLT)


7.

http://www.guildfordandwaverleyccg.nhs.uk/website/X45000/Files/Arthritic_Pain_Relief.pdf

Results. In patients with RA, relative to a separate control group, LLLT reduced pain by 70% relative to placebo and reduced morning stiffness by 27.5 min (95% CI –52.0 to –2.9), and increased tip to palm flexibility by 1.3 cm

  • Article2009 Nov;58(11):1401-6.

[Phototherapy for chronic pain treatment].

[Article in Japanese]

Ide Y1.

Author information

Abstract

Three types of machines are used in the field of phototherapy for chronic pain. One type is an instrument for low reactive level laser therapy (LLLT), one is an instrument for linear polarized infrared light irradiation (SUPER LIZER), and the last one is an instrument for Xenon light irradiation (beta EXCEL Xe10). The available machines for LLLT all project laser by semiconductor. The newest machine (MEDILASER SOFT PULSE10) has peak power of 10 W and mean power of 1 W. This machine is as safe as 1 W machine and is effective twice as deep as the 1 W machine. The irradiation by low reactive level laser induces hyperpolarization, decreased resistance of neuronal membrane, and increased intra-cellular ATP concentrations. The effects of low reactive level laser might be induced by the activation of ATP-dependent K channel. The significant analgesic effects of 1 W and 10 W LLLT were reported with double blind test. The significant analgesic effects of linear polarized near infrared light irradiation with double blind test were also reported. The effects of low reactive level laser upon the sympathetic nerve system were thought to result from its normalization of the overloaded sympathetic nerve system

J Rheumatol. 2000 Aug;27(8):1961-9.

Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis.

Brosseau L1Welch VWells GTugwell Pde Bie RGam AHarman KShea BMorin M.

Author information


8.

Abstract

OBJECTIVE:

Osteoarthritis (OA) and rheumatoid arthritis (RA) affect a large proportion of the population. Low level laser therapy (LLLT) was introduced as an alternative noninvasive treatment for RA and OA about 10 years ago, but its effectiveness is still controversial. We assessed the effectiveness of LLLT in the treatment of RA and OA.

METHODS:

A systematic review was conducted, following an a priori protocol, according to the methods recommended by the Cochrane Collaboration. Trials were identified by a literature search of Medline, Embase, and the Cochrane Controlled Trials Register. Only randomized controlled trials of LLLT for the treatment of patients with a clinical diagnosis of RA or OA were eligible. Thirteen trials were included, with 212 patients randomized to laser and 174 patients to placebo laser, and 68 patients received active laser on one hand and placebo on the opposite hand. Treatment duration ranged from 4 to 10 weeks. Followup was reported by only 2 trials for up to 3 months.

RESULTS:

In patients with RA, relative to a separate control group, LLLT reduced pain by 70% relative to placebo and reduced morning stiffness by 27.5 min (95% CI -52.0 to -2.9), and increased tip to palm flexibility by 1.3 cm (95% CI -1.7 to -0.8). Other outcomes such as functional assessment, range of motion, and local swelling were not different between groups. There were no significant differences between subgroups based on LLLT dosage, wavelength, site of application, or treatment length. In RA, relative to a control group using the opposite hand, there was no difference between control and treatment hand, but all hands were improved in terms of pain relief and disease activity. For OA, a total of 197 patients were randomized. Pain was assessed by 3 trials. The pooled estimate (random effects) showed no effect on pain (standardized mean difference -0.2, 95% CI -1.0 to +0.6), but there was statistically significant heterogeneity (p > 0.05). Other outcomes of joint tenderness, joint mobility, and strength were not significant.

CONCLUSION:

LLLT should be considered for short term relief of pain and morning stiffness in RA, particularly since it has few side effects. For OA, the results are conflicting in different studies and may depend on the method of application and other features of the LLLT. Clinicians and researchers should consistently report the characteristics of the LLLT device and the application techniques. New trials on LLLT should make use of standardized, validated outcomes. Despite some positive findings, this metaanalysis lacked data on how effectiveness of LLLT is affected by 4 factors: wavelength, treatment duration of LLLT, dosage, and site of application over nerves instead of joints. There is a need to investigate the effects of these factors on effectiveness of LLLT for RA and OA in randomized controlled clinical trials.

Effect of linear polarized near-infrared ray irradiation on the chemiluminescence of human neutrophils and serum opsonic activity.

Shiraishi M1Suzuki KNakaji SSugawara KSugita NSuzuki KJOhta S.

Author information


9.

Abstract

The purpose of this study was to investigate the in vitro effects of linear polarized near-infrared ray irradiation on neutrophil chemiluminescence (CL) and serum opsonic activity. We used luminol- and lucigenin-dependent CL to detect the affected reactive oxygen species production process of human neutrophils and measured serum opsonic activity based on luminol-dependent CL. The linear polarized near-infrared ray irradiation suppressed a maximum light emission (peak height) of luminol- and lucigenin-dependent CL in a dose-dependent manner. The findings suggested that the linear polarized near-infrared ray irradiation suppressed the superoxide anion and hypochlorite production of human neutrophils. The serum opsonic activity was decreased by linear polarized near-infrared ray irradiation, and this suppressive effect might be caused by inhibiting the activation of the classical and alternative complement pathway. Therefore, it is suggested that near-infrared ray irradiation may have an inhibitory effect against chronic pain via reduction of reactive oxygen species production and opsonic activity.

Copyright 1999 John Wiley & Sons, Ltd.

830 nm

Rheumatoid arthritis-affected temporomandibular joint pain analgesia by linear polarized near infrared irradiation.

Yokoyama K1Oku T.

Author information

Abstract

PURPOSE:

To describe a new short-term treatment for pain in rheumatoid arthritis (RA)-affected temporomandibular joint (TMJ).

CLINICAL FEATURES:

We investigated four female patients (age 42.8+/-26.0 yr) with chronic rheumatoid arthritis affecting a single TMJ. Patients had received antirheumatic drugs such as sodium aurothiomalate, and as a result showed no symptoms in other body joints. Linear polarized near infrared radiation using Super Lizer was applied weekly with and/or without jaw movement to the unilateral skin areas overlying the mandibular fossa, anterior articular tubercle, masseter muscle and posterior margin of the ramus of the mandible. The duration of irradiation to each point was two seconds on and ten seconds off per cycle and the intensity at each point was approximately 138 J x cm(-2) at a wavelength of 830 nm. Interincisal distance was measured with maximal mouth opening in the absence and presence of pain before and after each treatment. Additionally, subjective TMJ pain scores assessed using a visual analog scale were performed for painful maximal mouth opening before and after each irradiation. TMJ pain disappeared after only four treatments. Moreover, painless maximal mouth opening without pain after irradiation in three patients was on average improved to 5.3+/-2.1 mm. However, one case was observed where


10.

the opening length prior to irradiation did not improve, despite the fact that the RA-affected TMJ pain had disappeared.

CONCLUSION:

Application of linear polarized near infrared irradiation to patients with RA-affected TMJ pain is an effective and non-invasive short-term treatment.

Laser Ther. 2014 Jul 1;23(2):109-14. doi: 10.5978/islsm.14-OR-08.

Reduction of IL-20 Expression in Rheumatoid Arthritis by Linear Polarized Infrared Light Irradiation.

Imaoka A1Zhang L1Kuboyama N2Abiko Y1.

Author information

Abstract

BACKGROUND:

Low-level laser is being evaluated for treating rheumatoid arthritis (RA). Recently, the linear polarized infrared light (Super Lizer, SL) irradiation may also be useful for RA treatment. However, the molecular mechanism underlying the effectiveness of SL on RA is unclear. It has been IL-20 may involved in RA disease progression.

AIM:

To understand how SL action, we constructed the experimental model in vitro using human rheumatoid fibroblast-like synoviocyte (MH7A) and collagen induced (CIA) RA rat in vivo. We examined the effect of SL irradiation on IL-20 gene expression in MH7A and IL-20 protein production in CIA) rat joints.

MATERIALS AND METHODS:

MH7A was cultured and challenged with IL-1ß, then examined IL-20 and IL-20R mRNA level by DNA microarray. IL-20 protein expression was examined by immunohistochemistry using a specific antibody against rat IL-20.

RESULT:

Scatter plot analysis demonstrated that an increase in IL-20 gene expression by IL-1ß was reduced by SL irradiation, but IL-20R did not show a significant change. The Immunohistochemical analysis demonstrated a strong IL-20 staining in synovial membrane tissue of CIA rat joint, and SL irradiation significantly reduced the staining.

DISCUSSION:

Since IL-20 has been identified as an important cytokine in the pathogenesis of RA, the reduction of IL-20 expression by SL irradiation may be one of mechanisms in reduction of inflammation in RA joints by SL irradiation suggesting that SL irradiation may be useful for RA therapy.

KEYWORDS:

IL-20; Rheumatoid arthritis; linear polarized infrared light

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799034/         


11.

http://www.international.lutronic.com/healiteii

Is light-emitting diode phototherapy (LED-LLLT) really effective?

Won-Serk Kim1 and R Glen Calderhead2

CONCLUSIONS

In conclusion, based on the published data and the authors' own experience, LED phototherapy is proving to have more and more viable applications in many fields of medicine. However, it must always be remembered that not any old LED will do. In order to be effective, LED phototherapy must satisfy the following 3 criteria.

  • • The LED system being used must have first of all, and most importantly, the correct wavelength for the target cells or chromophores. At present, the published literature strongly suggests 830 nm for all aspects of wound healing, pain, anti-inflammatory treatment and skin rejuvenation, with a combination of 415 nm and 633 nm for light-only treatment of active inflammatory acne vulgaris. If the wavelength is incorrect, optimum absorption will not occur and as the first law of photobiology states, the Grotthus-Draper law, without absorption there can be no reaction.
  • • Secondly, the photon intensity, i.e., spectral irradiance or power density (W/cm2), must be adequate, or once again absorption of the photons will not be sufficient to achieve the desired result. If the intensity is too high, however, the photon energy will be transformed to excessive heat in the target tissue, and that is undesirable.
  • • Finally, the dose or fluence must also be adequate (J/cm2), but if the power density is too low, then prolonging the irradiation time to achieve the ideal energy density or dose will most likely not give an adequate final result, because the Bunsen-Roscoe law of reciprocity, the 2nd law of photobiology, does not hold true for low incident power densities.

Provided these three criteria are met, LED phototherapy does indeed work, and has many useful aspects in clinical practice for practitioners in many surgical specialities. As an exciting extension of the monotherapy approach with LED-LLLT, and even more importantly, the combination of appropriate LED phototherapy as an adjunct to many other surgical or nonsurgical approaches where the architecture of the patient's skin has been altered will almost certainly provide the clinician with even better results with


12.

less patient downtime, in a shorter healing period, and with excellent prophylaxis against obtrusive scar formation.

830 nm light-emitting diode low level light therapy (LED-LLLT) enhances wound healing: a preliminary study.

Min PK1Goo BL.

Author information

Abstract

BACKGROUND AND AIMS:

The application of light-emitting diodes in a number of clinical fields is expanding rapidly since the development in the late 1990s of the NASA LED. Wound healing is one field where low level light therapy with LEDs (LED-LLLT) has attracted attention for both accelerating wound healing and controlling sequelae. The present study evaluated LED-LLLT in 5 wounds of various etiologies.

SUBJECTS AND METHODS:

There were 5 patients with ages ranging from 7 to 54 years, comprising 2 males and 3 females. The study followed 5 wounds, namely 2 acute excoriation wounds; 1 acute/subacute dog bite with infection; 1 subacute post-filler ulcerated wound with necrotic ischemic tissue and secondary infection; and 1 subacute case of edema and infection of the lips with herpes simplex involvement after an illegal cosmetic tattoo operation. All patients were in varying degrees of pain. All wounds were treated with multiple sessions (daily, every other day or twice weekly) using an LED-LLLT system (830 nm, CW, irradiance of 100 mW/cm(2) and fluence of 60 J/cm(2)) till improvement was achieved.

RESULTS:

Full wound healing and control of infection and discomfort were achieved in all patients, with wound condition-mediated treatment periods ranging from 1 to 8 weeks. No recurrence of the herpes simplex case was seen in a 4-month follow-up.

CONCLUSIONS:

830 nm LED-LLLT successfully brought about accelerated healing in wounds of different etiologies and at different stages, and successfully controlled secondary infection. LED-LLLT was easy and pain-free to apply, and was well-tolerated by all patients. The good results warrant the design of controlled studies with a larger patient population.

KEYWORDS:

Excoriation wounds; Herpes simplex; Ischemic necrosis; LED-LLLT; Scar prophylaxis; Secondary infection

470nm

Lasers Surg Med. 2014 Dec;46(10):773-80. doi: 10.1002/lsm.22299. Epub 2014 Oct 31.


13.

Low level light therapy by LED of different wavelength induces angiogenesis and improves ischemic wound healing.

Dungel P1Hartinger JChaudary SSlezak PHofmann AHausner TStrassl MWintner ERedl HMittermayr R.

Author information

Abstract

BACKGROUND AND OBJECTIVE:

Low-level light therapy (LLLT) has been revealed as a potential means to improve wound healing. So far, most studies are being performed with irradiation in the red to near-infrared spectra. Recently, we showed that blue light (470 nm) can significantly influence biological systems such as nitric oxide (NO) metabolism and is able to release NO from nitrosyl-hemoglobin or mitochondrial protein complexes. Therefore, the aim of this study was to evaluate and compare the therapeutic value of blue or red light emitting diodes (LEDs) on wound healing in an ischemia disturbed rodent flap model.

STUDY DESIGN/MATERIALS AND METHODS:

An abdominal flap was rendered ischemic by ligation of one epigastric bundle and subjected to LED illumination with a wavelength of 470 nm (blue, n = 8) or 629 nm (red, n = 8) each at 50 mW/cm(2) and compared to a non-treated control group (n = 8). Illumination was performed for 10 minutes on five consecutive days.

RESULTS:

LED therapy with both wavelengths significantly increased angiogenesis in the sub-epidermal layer and intramuscularly (panniculus carnosus muscle) which was associated with significantly improved tissue perfusion 7 days after the ischemic insult. Accordingly, tissue necrosis was significantly reduced and shrinkage significantly less pronounced in the LED-treated groups of both wavelengths.

CONCLUSIONS:

LED treatment of ischemia challenged tissue improved early wound healing by enhancing angiogenesis irrespective of the wavelength thus delineating this noninvasive means as a potential, cost effective tool in complicated wounds.

© 2014 Wiley Periodicals, Inc.

KEYWORDS:

LED light therapy; angiogenesis; ischemic wound healing; nitric oxide; skin fla                

470 nm and 630 nm

Light therapy by blue LED improves wound healing in an excision model in rats.

Adamskaya N1Dungel PMittermayr RHartinger JFeichtinger GWassermann KRedl Hvan Griensven M.


14.

Author information

Abstract

BACKGROUND:

Low level light therapy (LLLT) is an attractive alternative to enhance wound healing. So far most studies are performed with red or infrared irradiation. However, we recently showed that blue light (470 nm) can significantly influence biological systems, improving perfusion by release of nitric oxide from nitrosyl complexes with haemoglobin in a skin flap model in rats. Here, we compared the effects of blue and red low level light by light-emitting diodes (LEDs) on in vivo wound healing in an excision wound model in rats.

METHODS:

Circular excision wounds were surgically created on the dorsum of each rat. Excisions on either the left or right side were illuminated post-OP and on five consecutive days for 10 min by LED at 470 nm or 630 nm with an intensity of 50 mW/cm(2),while protecting the contralateral side from exposure. In the control group, neither side was illuminated. On day 7 post-OP, we analysed planimetric and histological parameters, as well as expression of keratin-1, keratin-10 and keratin-17 on mRNA level.

RESULTS:

Illumination substantially influenced wound healing. Blue light significantly decreased wound size on day 7, which correlated with enhanced epithelialisation. Light also affected mRNA expression. Both wavelengths decreased keratin-1 mRNA on day 7 post-OP, while keratin-10 mRNA level was elevated in both light treated group compared to control. Keratin-17 mRNA was also elevated in the red light group, but was unchanged in the blue light group.

CONCLUSION:

In contrast to previous studies, we showed that also blue light significantly influences wound healing. Furthermore, our data suggest that light therapy can play an important role in normotrophic wound healing by affecting keratin expression. Illumination would provide an easily applicable, safe and cost-effective treatment of surface wounds

Green Light

        456nm 518nm 638nm                                                                                                                      Send to:

Wound Repair Regen. 2012 Mar-Apr;20(2):226-35. doi: 10.1111/j.1524-475X.2012.00771.x.

Green light emitting diodes accelerate wound healing: characterization of the effect and its molecular basis in vitro and in vivo.

Fushimi T1Inui SNakajima TOgasawara MHosokawa KItami S.

Author information


15.

Abstract

Because light-emitting diodes (LEDs) are low-coherent, quasimonochromatic, and nonthermal, they are an alternative for low level laser therapy, and have photobiostimulative effects on tissue repair. However, the molecular mechanism(s) are unclear, and potential effects of blue and/or green LEDs on wound healing are still unknown. Here, we investigated the effects of red (638 nm), blue (456 nm), and green (518 nm) LEDs on wound healing. In an in vivo study, wound sizes in the skin of ob/ob mice were significantly decreased on day 7 following exposure to green LEDs, and complete reepithelialization was accelerated by red and green LEDs compared with the control mice. To better understand the molecular mechanism(s) involved, we investigated the effects of LEDs on human fibroblasts in vitro by measuring mRNA and protein levels of cytokines secreted by fibroblasts during the process of wound healing and on the migration of HaCat keratinocytes. The results suggest that some cytokines are significantly increased by exposure to LEDs, especially leptin, IL-8, and VEGF, but only by green LEDs. The migration of HaCat keratinocytes was significantly promoted by red or green LEDs. In conclusion, we demonstrate that green LEDs promote wound healing by inducing migratory and proliferative mediators, whic suggests that not only red LEDs but also green LEDs can be a new powerful therapeutic strategy for wound healing.

© 2012 by the Wound Healing Society.

PMID:

Blue 441 green 532 red 633 nm

[A study of the effect of low-intensity laser radiation of the blue, green, and red spectral regions on the healing of experimental skin wounds in rats].

[Article in Russian]

Machneva TVProtopopov DMVladimirov IuAOsipov AN.

Abstract

The effect of low-intensity laser radiation of the blue (441.2 nm), green (532 nm), and red (632.8 nm) spectral regions on the healing of experimental skin wounds in rats has been studied. The effect of the traditionally applied laser radiation in the red region has been compared with the effect of laser radiation in the other spectral regions, assuming that, upon irradiation of wounds by lasers emitting in the blue and green regions, a similar effect can be achieved at lower doses. The following parameters characterizing the healing of experimental wounds were used: the functional activity of phagocytes of wound exudates, which was determined by luminol-dependent chemiluminescence, and their number; the antioxidant activity of wound exudates; and the rate of healing, which was determined as a change in the wound area. It was shown that irradiation with laser accelerated the healing of wounds in all cases. The exposure to laser radiations in the red (1.5 J/cm), blue, and green (0.75 J/cm2) spectral regions shortened the time of wound healing from 22 to 17 and 19 days, respectively. The functional activity of leukocytes after the exposure increased


16.

on day 5 after the infliction of the wound, whereas in the control it decreased. The superoxide dismutase activity increased in all experimental groups by day 5 after the operation. A maximum increase in the superoxide dismutase activity occurred after the exposure to laser radiation in the red region at a dose of 1.5 J/cm and in the blue and green spectral regions at a dose of 0.75 J/cm

904 and 632

A systematic review with procedural assessments and meta-analysis of low level laser therapy in lateral elbow tendinopathy (tennis elbow).

Bjordal JM1Lopes-Martins RAJoensen JCouppe CLjunggren AEStergioulas AJohnson MI.

Author information

Abstract

BACKGROUND:

Recent reviews have indicated that low level level laser therapy (LLLT) is ineffective in lateral elbow tendinopathy (LET) without assessing validity of treatment procedures and doses or the influence of prior steroid injections.

METHODS:

Systematic review with meta-analysis, with primary outcome measures of pain relief and/or global improvement and subgroup analyses of methodological quality, wavelengths and treatment procedures.

RESULTS:

18 randomised placebo-controlled trials (RCTs) were identified with 13 RCTs (730 patients) meeting the criteria for meta-analysis. 12 RCTs satisfied half or more of the methodological criteria. Publication bias was detected by Egger's graphical test, which showed a negative direction of bias. Ten of the trials included patients with poor prognosis caused by failed steroid injections or other treatment failures, or long symptom duration or severe baseline pain. The weighted mean difference (WMD) for pain relief was 10.2 mm [95% CI: 3.0 to 17.5] and the RR for global improvement was 1.36 [1.16 to 1.60]. Trials which targeted acupuncture points reported negative results, as did trials with wavelengths 820, 830 and 1064 nm. In a subgroup of five trials with 904 nm lasers and one trial with 632 nm wavelength where the lateral elbow tendon insertions were directly irradiated, WMD for pain relief was 17.2 mm [95% CI: 8.5 to 25.9] and 14.0 mm [95% CI: 7.4 to 20.6] respectively, while RR for global pain improvement was only reported for 904 nm at 1.53 [95% CI: 1.28 to 1.83]. LLLT doses in this subgroup ranged between 0.5 and 7.2 Joules. Secondary outcome measures of painfree grip strength, pain pressure threshold, sick leave and follow-up data from 3 to 8 weeks after the end of treatment, showed consistently significant results in favour of the same LLLT subgroup (p < 0.02). No serious side-effects were reported.

CONCLUSION:

LLLT administered with optimal doses of 904 nm and possibly 632 nm wavelengths directly to the lateral elbow tendon insertions, seem to offer short-term pain relief and less disability in

 

17.

LET, both alone and in conjunction with an exercise regimen. This finding contradicts the conclusions of previous reviews which failed to assess treatment procedures, wavelengths and optimal doses.

PMID:

18510742

G2009 Nov;58(11):1401-6.

[Phototherapy for chronic pain treatment].

[Article in Japanese]

Ide Y1.

Author information

Abstract

Three types of machines are used in the field of phototherapy for chronic pain. One type is an instrument for low reactive level laser therapy (LLLT), one is an instrument for linear polarized infrared light irradiation (SUPER LIZER), and the last one is an instrument for Xenon light irradiation (beta EXCEL Xe10). The available machines for LLLT all project laser by semiconductor. The newest machine (MEDILASER SOFT PULSE10) has peak power of 10 W and mean power of 1 W. This machine is as safe as 1 W machine and is effective twice as deep as the 1 W machine. The irradiation by low reactive level laser induces hyperpolarization, decreased resistance of neuronal membrane, and increased intra-cellular ATP concentrations. The effects of low reactive level laser might be induced by the activation of ATP-dependent K channel. The significant analgesic effects of 1 W and 10 W LLLT were reported with double blind test. The significant analgesic effects of linear polarized near infrared light irradiation with double blind test were also reported. The effects of low reactive level laser upon the sympathetic nerve system were thought to result from its normalization of the overloaded sympathetic nerve sy


MS and the Science

Light as might be a medicine (for MS and other degenerative diseases) Researchers explain how.

Multiple sclerosis (MS) causes progressive paralysis by destroying nerve cells and the spinal cord. It interrupts vision, balance and even thinking.


18.

On a suggestion from a colleague, Jeri-Anne Lyons decided to test how the disease responded to a radical therapy -- exposure to a certain wavelength of light called near-infrared (NIR).

"Never in a million years did I think it would help," says Lyons, an associate professor of biomedical sciences at the University of Wisconsin-Milwaukee (UWM), who studies the role of the immune response in MS.

But it did. In rodent models, early MS-like symptoms were treated with exposure to NIR light for a week, alternating with a week of no light. The clinical condition of the mice improved.

NIR (near Infrared light) light heals by ensuring that cytochrome oxidase binds with oxygen to turn on protectors and stimulate cell metabolism. Blue light, on the other hand, causes a toxic environment when the immune response has been triggered. That poisonous effect hastens healing of topical wounds by killing bacteria that cause infection.

Promising leads

Even more exciting is phototherapy's potential to improve a host of other degenerative diseases. Damaged mitochondria lead to a rise in destructive "free radicals," which play a key role in aging and cancer.

With so much success, why isn't phototherapy being used more widely?

"It's considered alternative therapy in Western medicine. It seems too simple for people to accept,"

http://www.sciencedaily.com/releases/2013/10/131022102227.htm

University of Wisconsin - Milwaukee

 

19.

Effects of Infrared Radiation on Skin Photo-Aging and Pigmentation

Ju Hee LeeMi Ryung Roh, and Kwang Hoon Lee

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687728/

Our study showed that IR radiation increased the amount of total soluble collagen and soluble elastin in fibroblasts and demonstrated that could result in clinical improvement in skin texture. 

 Fine wrinkles were at least fairly improved in all patients,

Amelioration of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice by Photobiomodulation Induced by 670 nm Light

The approved immunomodulatory agents for the treatment of multiple sclerosis (MS) are only partially effective. It is thought that the combination of immunomodulatory and neuroprotective strategies is necessary to prevent or reverse disease progression. Irradiation with far red/near infrared light, termed photobiomodulation, is a therapeutic approach for inflammatory and neurodegenerative diseases. Data suggests that near-infrared light functions through neuroprotective and anti-inflammatory mechanisms. 

Kamaldeen A. Muili,¤ Sandeep GopalakrishnanStacy L. MeyerJanis T. Eells, and Jeri-Anne Lyons*

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265499/

How sunlight may reduce the severity of multiple sclerosis

March 3, 2011

Source:

Wiley - Blackwell

Summary:

New research into the neurodegenerative disease, multiple sclerosis (MS) offers new insight into the link between sunlight, vitamin D3, and MS risk and severity. The research studies the relationship between the sunlight-dependent vitamin D3 hormone, immune cells, and the risk and severity of autoimmunity in an experimental model.

http://www.sciencedaily.com/releases/2011/03/110303065335.htm

 

20.

Common virus plus low sunlight exposure may increase risk of multiple sclerosis

Date:

April 19, 2011

Source:

American Academy of Neurology

Summary:

New research suggests that people who are exposed to low levels of sunlight coupled with a history of having a common virus known as mononucleosis may be at greater odds of developing multiple sclerosis than those without the virus.

Infectious mononucleosis is a disease caused by the Epstein-Barr virus, which is a Herpes virus that is extremely common but causes no symptoms in most people. However, when a person contracts the virus as a teenager or adult, it often leads to infectious mononucleosis

http://www.sciencedaily.com/releases/2011/04/110418161658.htm

 

"I am 53 years old and have had Multiple Sclerosis for 25 years. I work hard on holistic therapies with a limited budget and do quite well. My problems are; pain in my right foot, poor balance, lack of energy, poor bladder control and very sluggish bowels.

I have been using the Magic lamp/Light Therapy for 3 months and the changes are amazing:

  • The pain in my foot, which I have had for several years, is now 50% better.
  • My balance and walking is much better.
  • My energy level is significantly better.
  • My bowels are working perfectly. In fact, I had my bowels moved several times in the first few days and now go very regularly.

I now take no drugs at all. This means that MS is no longer in control of me, I am in control of it!

I have also suffered from depression because I have MS, which is common. But now, I feel happy and much more positive about my future.

This is only after 3 months, what’s going to happen after 6, 9 or 12 months.

Light therapy is truly amazing and is changing my life"

Ian, Lancashire


David Foster B.Sc.Dip.M Grad.Inst.M

Painfree15.com

2015

Disclaimer

Miles2goLtd, employees, certified distributors or agents so not make any warranties, expressed or implied, as to the use or effectiveness of any our products or services for a particular purpose. The user is solely responsible for determining whether our Light treatment is fit for a particular and suitable for the user’s method of application.
We believe that there is no healing power outside your body, and we do not claim that our light or service has healing power of any kind, and no claim as such is made or implied. The unit itself is a mixture of light, designed to be similar to the wavelengths used in the Independent evuidence, which might help as a tool to provide a safe, painless, non-invasive method of helping to stimulate cellular physiologically sensitive and skin sensory areas. While many people have been satisfactorily treated using light therapy as in the independent evidence, or have received some relief by this kind of method, no warranty is given or implied to the effectiveness, or otherwise, of this form of treatment or the programme offered. No responsibility is accepted for any treatment effects, condition progress, or sequel arising after treatment.
The information provided is for educational purposes only and is not intended to replace advice from your Doctor or other health care professional. We suggest you use our light system in conjunction with your health care professional’s recommendations.

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